The Future of the CYP2D6 Molecular Autopsy using Tramadol-Exposed Individuals

Molecular autopsy describes the use of genetic data to aid in determining cause and/or manner of death in situations where traditional medico-legal autopsy is undetermined. Seminal papers in this field have used genetic variation in the cytochrome p450 family 2, subfamily D, polypeptide 6 (CYP2D6) locus to classify four main metabolizer phenotypes: poor, intermediate, extensive, and ultrarapid.