Improved Tools for the Robust Analysis of Low Copy Number and Challenged DNA Samples

Blue and black helixLow copy number (LCN) typing is a general technique used for analyzing low-quantity DNA samples. Short tandem repeat (STR) testing on aged and extremely limited samples, such as “touch DNA” samples, has increased over the past decade. Samples with low quantities of template DNA are typically subjected to exaggerated stochastic effects during the polymerase chain reaction (PCR) that impact the reproducibility and reliability of DNA typing results.