This year marks the tenth anniversary of the complete human genome sequence. The Human Genome Project revealed a surprising fact: Only 1% of our genome encodes proteins. This equates to a paltry 20,000–25,000 genes. The function of the other 99% of our DNA remained a mystery. Shortly after the sequencing was completed, the National Human Genome Research Institute (NHGRI) launched a new research project, termed the Encyclopedia Of DNA Elements (ENCODE), to identify DNA elements and try to find a purpose for the other 99% of our DNA. This project has contributed greatly to our understanding of the human genome, as documented in the 30 ENCODE-related papers published in Nature, Genome Research and Genome Biology in 2012 (see the Nature web site. However, the ENCODE project is being used in an unforeseen way: to support an appeal to the recent US Supreme Court decision about the constitutionality of collection and analysis of DNA from arrestees.